Applied Computational Cancer Research

Prof. Dr. Florian Rambow

“Wolfgang und Gertrud Böttcher Stiftungsprofessur”
Stiftung Universitätsmedizin Essen

The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.

Contact

Girardethaus
Girardetstr. 8
House 8, 2nd floor
45131 Essen

Prof. Dr. Florian Rambow
Office

Projects

Recent Publications - see all...

J. Pozniak, D. Pedri, E. Landeloos, Y. Van Herck, A. Antoranz, L. Vanwynsberghe, A. Nowosad, N. Roda, S. Makhzami, G. Bervoets, L. F. Maciel, C. A. Pulido-Vicuna, L. Pollaris, R. Seurinck, F. Zhao, K. Flem-Karlsen, W. Damsky, L. Chen, D. Karagianni, S. Cinque, S. Kint, K. Vandereyken, B. Rombaut, T. Voet, F. Vernaillen, W. Annaert, D. Lambrechts, V. Boecxstaens, Y. Saeys, J. van den Oord, F. Bosisio, P. Karras, A. H. Shain, M. Bosenberg, E. Leucci, A. Paschen, F. Rambow, O. Bechter, and J. C. Marine. A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma. Cell. 2024. [doi] [url]

BibTeX

@article{RN194,
  author = {Pozniak, J. and Pedri, D. and Landeloos, E. and Van Herck, Y. and Antoranz, A. and Vanwynsberghe, L. and Nowosad, A. and Roda, N. and Makhzami, S. and Bervoets, G. and Maciel, L. F. and Pulido-Vicuna, C. A. and Pollaris, L. and Seurinck, R. and Zhao, F. and Flem-Karlsen, K. and Damsky, W. and Chen, L. and Karagianni, D. and Cinque, S. and Kint, S. and Vandereyken, K. and Rombaut, B. and Voet, T. and Vernaillen, F. and Annaert, W. and Lambrechts, D. and Boecxstaens, V. and Saeys, Y. and van den Oord, J. and Bosisio, F. and Karras, P. and Shain, A. H. and Bosenberg, M. and Leucci, E. and Paschen, A. and Rambow, F. and Bechter, O. and Marine, J. C.},
  title = {A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma},
  journal = {Cell},
  volume = {187},
  number = {1},
  pages = {166-183 e25},
  issn = {1097-4172 (Electronic)
  0092-8674 (Linking)},
  doi = {10.1016/j.cell.2023.11.037},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/38181739},
  year = {2024},
  type = {Journal Article}
}

R. Varaljai, L. Zimmer, Y. Al-Matary, P. Kaptein, L. J. Albrecht, B. Shannan, J. C. Brase, D. Gusenleitner, T. Amaral, N. Wyss, J. Utikal, L. Flatz, F. Rambow, H. C. Reinhardt, J. Dick, D. R. Engel, S. Horn, S. Ugurel, W. Sondermann, E. Livingstone, A. Sucker, A. Paschen, F. Zhao, J. M. Placke, J. M. Klose, W. P. Fendler, D. S. Thommen, I. Helfrich, D. Schadendorf, and A. Roesch. Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma. Nat Cancer. 2023. [doi] [url]

BibTeX

@article{RN195,
  author = {Varaljai, R. and Zimmer, L. and Al-Matary, Y. and Kaptein, P. and Albrecht, L. J. and Shannan, B. and Brase, J. C. and Gusenleitner, D. and Amaral, T. and Wyss, N. and Utikal, J. and Flatz, L. and Rambow, F. and Reinhardt, H. C. and Dick, J. and Engel, D. R. and Horn, S. and Ugurel, S. and Sondermann, W. and Livingstone, E. and Sucker, A. and Paschen, A. and Zhao, F. and Placke, J. M. and Klose, J. M. and Fendler, W. P. and Thommen, D. S. and Helfrich, I. and Schadendorf, D. and Roesch, A.},
  title = {Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma},
  journal = {Nat Cancer},
  volume = {4},
  number = {9},
  pages = {1292-1308},
  issn = {2662-1347 (Electronic)
  2662-1347 (Linking)},
  doi = {10.1038/s43018-023-00610-2},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/37525015},
  year = {2023},
  type = {Journal Article}
}

B. Kruse, A. C. Buzzai, N. Shridhar, A. D. Braun, S. Gellert, K. Knauth, J. Pozniak, J. Peters, P. Dittmann, M. Mengoni, T. C. van der Sluis, S. Hohn, A. Antoranz, A. Krone, Y. Fu, D. Yu, M. Essand, R. Geffers, D. Mougiakakos, S. Kahlfuss, H. Kashkar, E. Gaffal, F. M. Bosisio, O. Bechter, F. Rambow, J. C. Marine, W. Kastenmuller, A. J. Muller, and T. Tuting. CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours. Nature. 2023. [doi] [url]

BibTeX

@article{RN61,
  author = {Kruse, B. and Buzzai, A. C. and Shridhar, N. and Braun, A. D. and Gellert, S. and Knauth, K. and Pozniak, J. and Peters, J. and Dittmann, P. and Mengoni, M. and van der Sluis, T. C. and Hohn, S. and Antoranz, A. and Krone, A. and Fu, Y. and Yu, D. and Essand, M. and Geffers, R. and Mougiakakos, D. and Kahlfuss, S. and Kashkar, H. and Gaffal, E. and Bosisio, F. M. and Bechter, O. and Rambow, F. and Marine, J. C. and Kastenmuller, W. and Muller, A. J. and Tuting, T.},
  title = {CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours},
  journal = {Nature},
  issn = {1476-4687 (Electronic)
  0028-0836 (Linking)},
  doi = {10.1038/s41586-023-06199-x},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/37316667},
  year = {2023},
  type = {Journal Article}
}

A. Talebi, V. de Laat, X. Spotbeen, J. Dehairs, F. Rambow, A. Rogiers, F. Vanderhoydonc, L. Rizotto, M. Planque, G. Doglioni, S. Motamedi, D. Nittner, T. Roskams, P. Agostinis, O. Bechter, V. Boecxstaens, M. Garmyn, M. O’Farrell, A. Wagman, G. Kemble, E. Leucci, S. M. Fendt, J. C. Marine, and J. V. Swinnen. Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy. J Exp Clin Cancer Res. 2023. [doi] [url]

BibTeX

@article{RN62,
  author = {Talebi, A. and de Laat, V. and Spotbeen, X. and Dehairs, J. and Rambow, F. and Rogiers, A. and Vanderhoydonc, F. and Rizotto, L. and Planque, M. and Doglioni, G. and Motamedi, S. and Nittner, D. and Roskams, T. and Agostinis, P. and Bechter, O. and Boecxstaens, V. and Garmyn, M. and O'Farrell, M. and Wagman, A. and Kemble, G. and Leucci, E. and Fendt, S. M. and Marine, J. C. and Swinnen, J. V.},
  title = {Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy},
  journal = {J Exp Clin Cancer Res},
  volume = {42},
  number = {1},
  pages = {92},
  issn = {1756-9966 (Electronic)
  0392-9078 (Print)
  0392-9078 (Linking)},
  doi = {10.1186/s13046-023-02664-7},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/37072838},
  year = {2023},
  type = {Journal Article}
}

L. Martins Nascentes Melo, D. Herrera-Rios, D. Hinze, S. Loffek, I. Oezel, R. Turiello, J. Klein, S. Leonardelli, I. V. Westedt, Y. Al-Matary, S. Egea-Rodriguez, A. Brenzel, M. Bau, A. Sucker, E. Hadaschik, F. Wirsdorfer, H. Hanenberg, N. Uhlenbrock, D. Rauh, J. Pozniak, F. Rambow, J. C. Marine, M. Effern, N. Glodde, D. Schadendorf, J. Jablonska, M. Holzel, and I. Helfrich. Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma. J Immunother Cancer. 2023. [doi] [url]

BibTeX

@article{RN63,
  author = {Martins Nascentes Melo, L. and Herrera-Rios, D. and Hinze, D. and Loffek, S. and Oezel, I. and Turiello, R. and Klein, J. and Leonardelli, S. and Westedt, I. V. and Al-Matary, Y. and Egea-Rodriguez, S. and Brenzel, A. and Bau, M. and Sucker, A. and Hadaschik, E. and Wirsdorfer, F. and Hanenberg, H. and Uhlenbrock, N. and Rauh, D. and Pozniak, J. and Rambow, F. and Marine, J. C. and Effern, M. and Glodde, N. and Schadendorf, D. and Jablonska, J. and Holzel, M. and Helfrich, I.},
  title = {Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma},
  journal = {J Immunother Cancer},
  volume = {11},
  number = {4},
  issn = {2051-1426 (Electronic)
  2051-1426 (Linking)},
  doi = {10.1136/jitc-2021-004150},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/37028818},
  year = {2023},
  type = {Journal Article}
}