“Wolfgang und Gertrud Böttcher Stiftungsprofessur” Stiftung Universitätsmedizin Essen
The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.
Girardethaus Girardetstr. 2 House 2, 2nd floor 45131 Essen
Prof. Dr. Florian Rambow Office
@article{RN99, author = {Karras, P. and Bordeu, I. and Pozniak, J. and Nowosad, A. and Pazzi, C. and Van Raemdonck, N. and Landeloos, E. and Van Herck, Y. and Pedri, D. and Bervoets, G. and Makhzami, S. and Khoo, J. H. and Pavie, B. and Lamote, J. and Marin-Bejar, O. and Dewaele, M. and Liang, H. and Zhang, X. and Hua, Y. and Wouters, J. and Browaeys, R. and Bergers, G. and Saeys, Y. and Bosisio, F. and van den Oord, J. and Lambrechts, D. and Rustgi, A. K. and Bechter, O. and Blanpain, C. and Simons, B. D. and Rambow, F. and Marine, J. C.}, title = {A cellular hierarchy in melanoma uncouples growth and metastasis}, journal = {Nature}, volume = {610}, number = {7930}, pages = {190-198}, issn = {1476-4687 (Electronic) 0028-0836 (Linking)}, doi = {10.1038/s41586-022-05242-7}, url = {https://www.ncbi.nlm.nih.gov/pubmed/36131018}, year = {2022}, type = {Journal Article} }
@article{Pozniak2022.08.11.502598, author = {Pozniak, Joanna and Pedri, Dennis and Landeloos, Ewout and Herck, Yannick Van and Antoranz, Asier and Karras, Panagiotis and Nowosad, Ada and Makhzami, Samira and Bervoets, Greet and Dewaele, Michael and Vanwynsberghe, Lukas and Cinque, Sonia and Kint, Sam and Vandereyken, Katy and Voet, Thierry and Vernaillen, Frank and Annaert, Wim and Lambrechts, Diether and Boecxstaens, Veerle and van den Oord, Joost and Bosisio, Francesca and Leucci, Eleonora and Rambow, Florian and Bechter, Oliver and Marine, Jean-Christophe}, title = {A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma}, elocation-id = {2022.08.11.502598}, year = {2022}, doi = {10.1101/2022.08.11.502598}, publisher = {Cold Spring Harbor Laboratory}, url = {https://www.biorxiv.org/content/early/2022/08/13/2022.08.11.502598}, eprint = {https://www.biorxiv.org/content/early/2022/08/13/2022.08.11.502598.full.pdf}, journal = {bioRxiv} }
@article{RN48, author = {Verginadis, II and Avgousti, H. and Monslow, J. and Skoufos, G. and Chinga, F. and Kim, K. and Leli, N. M. and Karagounis, I. V. and Bell, B. I. and Velalopoulou, A. and Salinas, C. S. and Wu, V. S. and Li, Y. and Ye, J. and Scott, D. A. and Osterman, A. L. and Sengupta, A. and Weljie, A. and Huang, M. and Zhang, D. and Fan, Y. and Radaelli, E. and Tobias, J. W. and Rambow, F. and Karras, P. and Marine, J. C. and Xu, X. and Hatzigeorgiou, A. G. and Ryeom, S. and Diehl, J. A. and Fuchs, S. Y. and Pure, E. and Koumenis, C.}, title = {A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression}, journal = {Nat Cell Biol}, volume = {24}, number = {6}, pages = {940-953}, issn = {1476-4679 (Electronic) 1465-7392 (Linking)}, doi = {10.1038/s41556-022-00918-8}, url = {https://www.ncbi.nlm.nih.gov/pubmed/35654839}, year = {2022}, type = {Journal Article} }
@article{RN55, author = {Pedri, D. and Karras, P. and Landeloos, E. and Marine, J. C. and Rambow, F.}, title = {Epithelial-to-mesenchymal-like transition events in melanoma}, journal = {FEBS J}, volume = {289}, number = {5}, pages = {1352-1368}, issn = {1742-4658 (Electronic) 1742-464X (Linking)}, doi = {10.1111/febs.16021}, url = {https://www.ncbi.nlm.nih.gov/pubmed/33999497}, year = {2022}, type = {Journal Article} }
@article{RN52, author = {Talon, I. and Janiszewski, A. and Theeuwes, B. and Lefevre, T. and Song, J. and Bervoets, G. and Vanheer, L. and De Geest, N. and Poovathingal, S. and Allsop, R. and Marine, J. C. and Rambow, F. and Voet, T. and Pasque, V.}, title = {Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals}, journal = {Genome Biol}, volume = {22}, number = {1}, pages = {302}, issn = {1474-760X (Electronic) 1474-7596 (Linking)}, doi = {10.1186/s13059-021-02518-5}, url = {https://www.ncbi.nlm.nih.gov/pubmed/34724962}, year = {2021}, type = {Journal Article} }
florian.rambow@uk-essen.de