“Wolfgang und Gertrud Böttcher Stiftungsprofessur” Stiftung Universitätsmedizin Essen
The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.
Girardethaus Girardetstr. 8 House 8, 2nd floor 45131 Essen
Prof. Dr. Florian Rambow Office
@article{RN61, author = {Kruse, B. and Buzzai, A. C. and Shridhar, N. and Braun, A. D. and Gellert, S. and Knauth, K. and Pozniak, J. and Peters, J. and Dittmann, P. and Mengoni, M. and van der Sluis, T. C. and Hohn, S. and Antoranz, A. and Krone, A. and Fu, Y. and Yu, D. and Essand, M. and Geffers, R. and Mougiakakos, D. and Kahlfuss, S. and Kashkar, H. and Gaffal, E. and Bosisio, F. M. and Bechter, O. and Rambow, F. and Marine, J. C. and Kastenmuller, W. and Muller, A. J. and Tuting, T.}, title = {CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours}, journal = {Nature}, issn = {1476-4687 (Electronic) 0028-0836 (Linking)}, doi = {10.1038/s41586-023-06199-x}, url = {https://www.ncbi.nlm.nih.gov/pubmed/37316667}, year = {2023}, type = {Journal Article} }
@article{RN62, author = {Talebi, A. and de Laat, V. and Spotbeen, X. and Dehairs, J. and Rambow, F. and Rogiers, A. and Vanderhoydonc, F. and Rizotto, L. and Planque, M. and Doglioni, G. and Motamedi, S. and Nittner, D. and Roskams, T. and Agostinis, P. and Bechter, O. and Boecxstaens, V. and Garmyn, M. and O'Farrell, M. and Wagman, A. and Kemble, G. and Leucci, E. and Fendt, S. M. and Marine, J. C. and Swinnen, J. V.}, title = {Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy}, journal = {J Exp Clin Cancer Res}, volume = {42}, number = {1}, pages = {92}, issn = {1756-9966 (Electronic) 0392-9078 (Print) 0392-9078 (Linking)}, doi = {10.1186/s13046-023-02664-7}, url = {https://www.ncbi.nlm.nih.gov/pubmed/37072838}, year = {2023}, type = {Journal Article} }
@article{RN63, author = {Martins Nascentes Melo, L. and Herrera-Rios, D. and Hinze, D. and Loffek, S. and Oezel, I. and Turiello, R. and Klein, J. and Leonardelli, S. and Westedt, I. V. and Al-Matary, Y. and Egea-Rodriguez, S. and Brenzel, A. and Bau, M. and Sucker, A. and Hadaschik, E. and Wirsdorfer, F. and Hanenberg, H. and Uhlenbrock, N. and Rauh, D. and Pozniak, J. and Rambow, F. and Marine, J. C. and Effern, M. and Glodde, N. and Schadendorf, D. and Jablonska, J. and Holzel, M. and Helfrich, I.}, title = {Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma}, journal = {J Immunother Cancer}, volume = {11}, number = {4}, issn = {2051-1426 (Electronic) 2051-1426 (Linking)}, doi = {10.1136/jitc-2021-004150}, url = {https://www.ncbi.nlm.nih.gov/pubmed/37028818}, year = {2023}, type = {Journal Article} }
@article{RN64, author = {Shoji, K. F. and Bayet, E. and Leverrier-Penna, S. and Le Devedec, D. and Mallavialle, A. and Marionneau-Lambot, S. and Rambow, F. and Perret, R. and Joussaume, A. and Viel, R. and Fautrel, A. and Khammari, A. and Constantin, B. and Tartare-Deckert, S. and Penna, A.}, title = {The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential}, journal = {EMBO Rep}, volume = {24}, number = {4}, pages = {e55069}, issn = {1469-3178 (Electronic) 1469-221X (Print) 1469-221X (Linking)}, doi = {10.15252/embr.202255069}, url = {https://www.ncbi.nlm.nih.gov/pubmed/36744297}, year = {2023}, type = {Journal Article} }
@article{RN65, author = {Hua, Y. and Vella, G. and Rambow, F. and Allen, E. and Martinez, A. A. and Duhamel, M. and Takeda, A. and Jalkanen, S. and Junius, S. and Smeets, A. and Nittner, D. and Dimmeler, S. and Hehlgans, T. and Liston, A. and Bosisio, F. M. and Floris, G. and Laoui, D. and Hollmen, M. and Lambrechts, D. and Merchiers, P. and Marine, J. C. and Schlenner, S. and Bergers, G.}, title = {Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1(+) T lymphocyte niches through a feed-forward loop}, journal = {Cancer Cell}, volume = {41}, number = {1}, pages = {226}, issn = {1878-3686 (Electronic) 1535-6108 (Linking)}, doi = {10.1016/j.ccell.2022.12.006}, url = {https://www.ncbi.nlm.nih.gov/pubmed/36626867}, year = {2023}, type = {Journal Article} }
florian.rambow@uk-essen.de
andrea.tonk@uk-essen.de Phone: +4920172377825
samira.rambow-makhzami@uk-essen.de
yichao.hua@uk-essen.de