Applied Computational Cancer Research

Prof. Dr. Florian Rambow

“Wolfgang und Gertrud Böttcher Stiftungsprofessur”
Stiftung Universitätsmedizin Essen

The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.

Contact

Girardethaus
Girardetstr. 8
House 8, 2nd floor
45131 Essen

Prof. Dr. Florian Rambow
Office

Projects

Recent Publications - see all...

G. Lodde, J. Dollani, W. Galetzka, P. Mohr, F. Meier, R. Gutzmer, M. Weichenthal, J. Utikal, R. Herbst, U. Leiter, C. Pfohler, B. Schilling, P. Terheyden, C. Berking, A. Sucker, A. Stang, F. Rambow, D. Tilkorn, A. Roesch, A. Zaremba, L. Zimmer, A. Tasdogan, D. Schadendorf, S. Ugurel, K. Griewank, and E. Livingstone. Melanoma of unknown primary shows oncogenic pattern and clinical course of sun-exposed melanoma. Br J Dermatol. 2026. [doi] [url]

BibTeX

@article{RN342,
  author = {Lodde, G. and Dollani, J. and Galetzka, W. and Mohr, P. and Meier, F. and Gutzmer, R. and Weichenthal, M. and Utikal, J. and Herbst, R. and Leiter, U. and Pfohler, C. and Schilling, B. and Terheyden, P. and Berking, C. and Sucker, A. and Stang, A. and Rambow, F. and Tilkorn, D. and Roesch, A. and Zaremba, A. and Zimmer, L. and Tasdogan, A. and Schadendorf, D. and Ugurel, S. and Griewank, K. and Livingstone, E.},
  title = {Melanoma of unknown primary shows oncogenic pattern and clinical course of sun-exposed melanoma},
  journal = {Br J Dermatol},
  issn = {1365-2133 (Electronic)
  0007-0963 (Linking)},
  doi = {10.1093/bjd/ljaf499},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/41719057},
  year = {2026},
  type = {Journal Article}
}

M. Baures, A. S. Vieira Aleixo, E. Pacreau, A. Koshy, V. Friedrich, M. Diedisheim, M. Raigel, Y. Hua, C. Dariane, F. Boutillon, L. Kenner, J. C. Marine, G. Laverny, D. Metzger, F. Rambow, J. E. Guidotti, and V. Goffin. Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy. EMBO Mol Med. 2026. [doi] [url]

BibTeX

@article{RN343,
  author = {Baures, M. and Vieira Aleixo, A. S. and Pacreau, E. and Koshy, A. and Friedrich, V. and Diedisheim, M. and Raigel, M. and Hua, Y. and Dariane, C. and Boutillon, F. and Kenner, L. and Marine, J. C. and Laverny, G. and Metzger, D. and Rambow, F. and Guidotti, J. E. and Goffin, V.},
  title = {Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy},
  journal = {EMBO Mol Med},
  issn = {1757-4684 (Electronic)
  1757-4676 (Linking)},
  doi = {10.1038/s44321-026-00375-y},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/41629661},
  year = {2026},
  type = {Journal Article}
}

C. M. Thielmann, J. A. Seier, L. Schielke, L. J. Albrecht, L. Zimmer, E. Livingstone, A. Zaremba, G. Lodde, J. Dissemond, W. Sondermann, F. Krefting, A. Tasdogan, A. Roesch, E. Hadaschik, F. Rambow, K. Griewank, S. Ugurel, D. Schadendorf, and J. M. Placke. Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients. Front Immunol. 2025. [doi] [url]

BibTeX

@article{RN268,
  author = {Thielmann, C. M. and Seier, J. A. and Schielke, L. and Albrecht, L. J. and Zimmer, L. and Livingstone, E. and Zaremba, A. and Lodde, G. and Dissemond, J. and Sondermann, W. and Krefting, F. and Tasdogan, A. and Roesch, A. and Hadaschik, E. and Rambow, F. and Griewank, K. and Ugurel, S. and Schadendorf, D. and Placke, J. M.},
  title = {Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients},
  journal = {Front Immunol},
  volume = {16},
  pages = {1727312},
  issn = {1664-3224 (Electronic)
  1664-3224 (Linking)},
  doi = {10.3389/fimmu.2025.1727312},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/41476990},
  year = {2025},
  type = {Journal Article}
}

K. Theunis, S. Vanuytven, I. Claes, J. Geurts, F. Rambow, D. Brown, M. Van Der Haegen, O. Marin-Bejar, A. Rogiers, N. Van Raemdonck, E. Leucci, J. Demeulemeester, A. Sifrim, J. C. Marine, and T. Voet. Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones. Nucleic Acids Res. 2025. [doi] [url]

BibTeX

@article{RN267,
  author = {Theunis, K. and Vanuytven, S. and Claes, I. and Geurts, J. and Rambow, F. and Brown, D. and Van Der Haegen, M. and Marin-Bejar, O. and Rogiers, A. and Van Raemdonck, N. and Leucci, E. and Demeulemeester, J. and Sifrim, A. and Marine, J. C. and Voet, T.},
  title = {Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones},
  journal = {Nucleic Acids Res},
  volume = {53},
  number = {6},
  issn = {1362-4962 (Electronic)
  0305-1048 (Print)
  0305-1048 (Linking)},
  doi = {10.1093/nar/gkaf173},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/40138718},
  year = {2025},
  type = {Journal Article}
}

Y. Hua, L. Weng, F. Zhao, and F. Rambow. SeuratExtend: streamlining single-cell RNA-seq analysis through an integrated and intuitive framework. Gigascience. 2025. [doi] [url]

BibTeX

@article{RN265,
  author = {Hua, Y. and Weng, L. and Zhao, F. and Rambow, F.},
  title = {SeuratExtend: streamlining single-cell RNA-seq analysis through an integrated and intuitive framework},
  journal = {Gigascience},
  volume = {14},
  issn = {2047-217X (Electronic)
  2047-217X (Linking)},
  doi = {10.1093/gigascience/giaf076},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/40627366},
  year = {2025},
  type = {Journal Article}
}